Assays for disease-associated crystals in biological samples
US8153436B2 · kind B2 · utility
Assignees
Inventor
Key dates
| Filing date | Feb 14, 2008 |
| Grant date | Apr 10, 2012 |
| Priority date | — |
| Expiry date | Nov 8, 2028 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/107
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods of assaying for disease-associated crystal species in biological samples are described. Such methods involve contacting a patient sample with an excess of a detectable crystal-tagging compound reactive with a plurality of crystal species under conditions that allow the detectable crystal-tagging compound to react with a plurality of crystal species, if present, to form tagged crystal species complexes. Substantially all unreacted tagging compound is then removed. If desired, chemical, enzymatic, or physical treatment can be used to selectively degrade some, but not, of the tagged crystal species. Assessment of soluble versus crystal-associated label is then performed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.