Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems
US8153446B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | May 13, 2009 |
| Grant date | Apr 10, 2012 |
| Priority date | — |
| Expiry date | Jul 2, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/80
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.