Synthesis of glycerolipid carbamates and dicarbamates and their use as an antitumor compounds
US8153615B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Jun 12, 2006 |
| Grant date | Apr 10, 2012 |
| Priority date | — |
| Expiry date | Aug 19, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The syntheses and in vitro antitumor properties of carbamate-containing, dicarbamate-containing, and ureido-containing phospholipid compounds that have an ether linkage at the C-1 position of a glycerol backbone, a carbamate, dicarbamate, or ureido moiety at the C-2 position of the glycerol backbone, and a phosphocholine, phosphonocholine, or glycoside moiety at the C-3 position of the glycerol backbone are described. The synthesis and antiproliferative activity of ether lipids with a naphthol moiety at the C-1 position are also described. These compounds were shown to be potent inhibitors of cancer cell growth. These compounds are useful for killing cancer cells and treating cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.