Aryl- and heteroaryl-ethyl-acylguanidine derivatives, their preparation and their application in therapeutics

US8153647B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Jozsef Zsolt Bocskei · Antony, FR
• Gary MCCORT · Paris, FR
• Hans Matter · Langenselbold, DE
• Henning Steinhagen · Pocking, DE
• Bérangère Thiers · Paris, FR

Key dates

• Filing date: Dec 15, 2008
• Grant date: Apr 10, 2012
• Expiry date: Aug 30, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are compounds according to formula (I):wherein A, Q, X, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 are as defined herein. The disclosure also relates to pharmaceutical compositions containing a compound of formula (I), to processes for preparing the compounds of formula (I), and to methods of using the compounds of formula (I).