Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

US8153651B2 · kind B2 · utility

Assignee

• EVOTEC AG · DE

Inventors

• Matthew Cox · Farmingdale, US
• Donogh John Roger O'Mahony · San Mateo, US
• Maria de los Angeles Estiarte-Martinez · San Francisco, US
• Tadashi Kawashima · Sandwich, GB
• Satoshi Nagayama · Miyoshi, JP
• Yuji Shishido · Ebeye, US
• Hirotaka Tanaka · Gifu, JP
• Matthew Duncton · San Francisco, US
• Andrew Antony Calabrese · San Diego, US

Key dates

• Filing date: Nov 13, 2008
• Grant date: Apr 10, 2012
• Expiry date: Nov 13, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds are disclosed that have a formula represented by the following:The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.