Piperidyl-propane-thiol CCR3 modulators

US8153660B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim International GmbH · DE

Inventors

• Domnic Martyres · Biberach, DE
• Matthias Hoffmann · Mittelbiberach, DE
• Peter Seither · Biberach an der Riß, DE
• Thierry Bouyssou · Mietingen, DE

Key dates

• Filing date: Oct 25, 2007
• Grant date: Apr 10, 2012
• Expiry date: Aug 8, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

One object of the present invention are novel substituted piperidyl-propane-thiols of the formula (1), wherein R1, R2, R3 and R4 are defined as below. Another object of the present invention is to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, more particularly to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.