Composition for palladium-mediated cleavage of peptides containing CXC, CXH or CHM sequences
US8153762B2 · kind B2 · utility
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7References
27Claims
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Key dates
| Filing date | Aug 28, 2008 |
| Grant date | Apr 10, 2012 |
| Priority date | — |
| Expiry date | May 9, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K7/06
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention provides a process for amidating a desired peptide comprising cleaving a substrate polypeptide at a X1-cysteine sequence, wherein X1 is the amino acid at the peptide carboxyl-terminus and cysteine is the first amino acid of a palladium cleavage site comprising the sequence cysteine-X2-X3, wherein X2 is any amino acid, X3 is an amino acid selected from the group consisting of cysteine, histidine, or methionine, and wherein the carboxyl-terminus of the peptide is amidated upon cleavage at the X1-cysteine sequence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.