Azacytosine derivatives useful as antiviral agents

US8153787B2 · kind B2 · utility

Assignees

• K.U. Leuven Research & Development · BE
• INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY ACADEMY OF SCIENCES OF THE CZECH REPUBLIC · CZ

Inventors

• Antonin Holy · Praha, CZ
• Marcela Krecmerova · Praha, CZ
• Alois Piskala · Praha, CZ
• Graciela Andrei · Leuven, BE
• Robert Snoeck · Woluwe-Saint-Lambert - Sint-Lambrechts-Woluwe, BE
• Erik De Clercq · Lovenjoel, BE
• Johan Neyts · Namur, BE
• Lieve Naesens · Puurs, BE

Key dates

• Filing date: Dec 8, 2006
• Grant date: Apr 10, 2012
• Expiry date: Sep 30, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6518
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides 5-azacytosine derivatives with antiviral activity, specifically having viral replication inhibiting properties, more particularly in DNA viruses such as pox-, papilloma- and herpes viruses in humans. The invention also provides pharmaceutical compositions comprising such 5-azacytosine derivatives as active ingredients in combination with pharmaceutically acceptable carriers, which are useful for the treatment of subjects suffering from viral infections.