Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors
US8153792B2 · kind B2 · utility
1Cited by
1References
22Claims
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Key dates
| Filing date | Feb 13, 2008 |
| Grant date | Apr 10, 2012 |
| Priority date | — |
| Expiry date | May 16, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to an industrial process of preparing pharmaceutical compounds having the formula (1) which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit and bcr-abl inhibitors. The groups R1 and R2, identical or different, represent each a hydrogen, halogen atom, an alkyl, an alkoxy, a trifluoromethyl, an amino, an alkylamino, a dialkylamino, a solubilising group; m is 0-5 and n is 0-4; the group R3 represents an aryl or an heteroaryl group as described in claims herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.