Systems for releasing active ingredients, based on biodegradable or biocompatible polymers with a shape memory effect

US8158143B2 · kind B2 · utility

Assignee

• Helmholtz-Zentrum Geesthacht Zentrum für Material- und Küstenforschung GmbH

Inventors

• Andreas Lendlein · Berlin, DE
• Susi Steuer · Aachen, DE
• Annika Tuleweit · Aachen, DE

Key dates

• Filing date: Jul 10, 2003
• Grant date: Apr 17, 2012
• Expiry date: Oct 26, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2300/604
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A drug release system is disclosed comprising a laminate structure comprising at least one layer comprising a matrix made from a shape memory material and at least one drug dispersed in the matrix, and layers from a shape memory material not containing a drug and sandwiching the at least one layer comprising the drug(s) on both surfaces, wherein the shape memory material of the layers not containing a drug, after triggering of the shape memory effect, controls the release rate of the drug(s). Another embodiment comprises at least one drug, a reservoir for receiving the drug(s), and at least one of a coating and a membrane closing the reservoir, wherein one of a material for the reservoir and a material for the coating or membrane is made from a shape memory material and wherein the shape memory material, after triggering the shape memory effect, controls the rate of release of the drug(s).