Threo-DOPS controlled release formulation
US8158149B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 29, 2007 |
| Grant date | Apr 17, 2012 |
| Priority date | — |
| Expiry date | Dec 22, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/198
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.