Imaging agents for protein misfolding
US8158380B2 · kind B2 · utility
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Key dates
| Filing date | Feb 11, 2008 |
| Grant date | Apr 17, 2012 |
| Priority date | — |
| Expiry date | Nov 17, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/4709
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Charged and neutral small fluorescent molecules based upon the styryl scaffold are useful as imaging agents for misfolded proteins such as amyloid plaque. Charged molecules are prepared using pyrrolidine catalyzed reactions by solution-phase synthesis. Neutral styryl molecules are prepared using acetic anhydride catalyzed reactions, Horner-Emmons reactions or Wittig reactions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.