Substituted pyrrolopyridines and pyrazolopyridines as kinase modulators

US8158647B2 · kind B2 · utility

Assignee

• SGX Pharmaceuticals, Inc. · US

Inventors

• Jeffrey M. Blaney · Vero Beach, US
• Andreas Gosberg · San Diego, US
• Stefan N. Gradl · San Diego, US
• Gavin Hirst · Princeton, US
• Stephanie Hopkins · Poway, US
• Paul A. Sprengeler · San Diego, US
• Ruo Steensma · Weehawken, US
• Johnny Uy · San Diego, US

Key dates

• Filing date: May 29, 2008
• Grant date: Apr 17, 2012
• Expiry date: Dec 23, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are substituted pyrrolopyridine heterocycles and substituted pyrazolopyridine heterocycles, pharmaceutical compositions comprising said heterocycles and methods of using said heterocycles in the treatment of disease. The heterocycles disclosed herein function as kinase modulators and have utility in the treatment of diseases such as cancer, allergy, asthma, inflammation, obstructive airway disease, autoimmune diseases, metabolic disease, infection, CNS disease, brain tumor, obesity, asthma, hematological disorder, degenerative neural disease, cardiovascular disease, or disease associated with angiogenesis, neovascularization, or vasculogenesis.