Demethylation of 14-hydroxy substituted alkaloid derivatives
US8158793B2 · kind B2 · utility
0Cited by
1References
28Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 24, 2008 |
| Grant date | Apr 17, 2012 |
| Priority date | — |
| Expiry date | Aug 21, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention is directed to a method for demethylating 14-hydroxy substituted alkaloid derivatives, in particular of 14-hydroxy-17-methyl-4,5-epoxymorphinane-6-on-derivatives. This is achieved by reacting a starting compound with a compound of general formula R1OOC—N═N—COOR2 in a suitable solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.