Nucleic acid size detection method
US8163480B2 · kind B2 · utility
1Cited by
14References
13Claims
0Family size
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Key dates
| Filing date | Oct 5, 2006 |
| Grant date | Apr 24, 2012 |
| Priority date | — |
| Expiry date | Oct 6, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/17
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods of determining the size of a particular nucleic acid segment of interest in a sample of nucleic acids through fragmentation of DNA, size fractionation, an optional second fragmentation, and identification using a marker sequence. In particular aspects, an expansion or reduction of tandem repeat sequences can be detected. In further aspects, carriers and individuals afflicted with fragile X syndrome or other diseases associated with tandem repeats can be distinguished from normal individuals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.