Methods for the identification of LRRK2 interacting molecules

US8163511B2 · kind B2 · utility

Assignee

• Cellzome Limited · GB

Inventors

• Gerard Drewes · Hamburg, DE
• Carsten Hopf · Mannheim, DE
• Valerie Reader · Linton, US

Key dates

• Filing date: Mar 13, 2007
• Grant date: Apr 24, 2012
• Expiry date: Mar 13, 2027

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/2835
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention features methods for the identification of leucine-rich kinase 2 (LRRK2) inhibitors using indol ligand 91. Generally, these methods include identifying compounds that compete with indol ligand 91 for binding to LRRK2.