Patent · US Active

Dual chain synthetic heparin-binding growth factor analogs

US8163717B2 · kind B2 · utility

7Cited by

129References

8Claims

0Family size

Assignee

BioSurface Engineering Technologies, Inc. · US

Inventors

Paul O. Zamora · Gaithersburg, US
Louis A. Pena · Poquott, US
Xinhua Lin · Plainview, US

Key dates

Filing date	Oct 6, 2009
Grant date	Apr 24, 2012
Priority date	—
Expiry date	Dec 30, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a second linker, which may be a hydrophobic second linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.