Beta-secretase modulators and methods of use
US8163766B2 · kind B2 · utility
Assignee
Inventors
- Wenge Zhong
- Stephen Hitchcock
- Vinod F. Patel
- Yuan Cheng
- Michael Croghan
- Randall W. Hungate
- Daniel La
- Patricia Lopez
- Matthew Kaller
- Holger Monenschein
- Thomas Nguyen
- Thomas Nixey
- Lewis D. Pennington
- Matthew Weiss
- Ted Judd
- Russell Graceffa
- Qiufen Xue
- Charles Kreiman
- Brian K. Albrecht
- Denise Andersen
- Michael D. Bartberger
- James Brown
- Ryan Brown
- Stuart C. Chaffee
- Scott Harried
- Craig E. Masse
- Bryant Yang
Key dates
| Filing date | Oct 21, 2010 |
| Grant date | Apr 24, 2012 |
| Priority date | — |
| Expiry date | Oct 21, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula Iwherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.