Nicotine receptor agonists in stem cell and progenitor cell recruitment

US8163780B2 · kind B2 · utility

Assignee

• The Board of Trustees of the Leland Stanford Jr. University · US

Inventors

• John Cooke · Palo Alto, US
• Frances L. Johnson · Iowa City, US
• Anjali Pathak · Campbell, US
• James Jang · San Bruno, US
• Philip Tsao · San Jose, US
• Christopher Heeschen · Frankfurt am Main, DE

Key dates

• Filing date: Nov 16, 2010
• Grant date: Apr 24, 2012
• Expiry date: Nov 16, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other nicotine receptor agonist. The methods of the invention can be used in, for example, treatment of conditions amenable to treatment by recruitment of bone marrow-derived stem cells (e.g., neutropenia).