Ribonucleotide reductase inhibitors and methods of use
US8163783B2 · kind B2 · utility
3Cited by
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8Claims
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Key dates
| Filing date | Apr 25, 2011 |
| Grant date | Apr 24, 2012 |
| Priority date | — |
| Expiry date | Apr 25, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/12
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme. These inhibitors may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.