Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates and methods of making said conjugates
US8163888B2 · kind B2 · utility
44Cited by
39References
53Claims
0Family size
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Key dates
| Filing date | Oct 29, 2007 |
| Grant date | Apr 24, 2012 |
| Priority date | — |
| Expiry date | Oct 29, 2027 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A50/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.