Patent · US Active

Process for the preparation of 8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride

US8163922B2 · kind B2 · utility

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1References

22Claims

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Assignee

Chiesi Farmaceutici S.p.A. · IT

Inventors

Fausto Pivetti · Parma, IT
Monica Bocchi · Parma, IT
Maurizio Delcanale · Parma, IT

Key dates

Filing date	Jul 30, 2009
Grant date	Apr 24, 2012
Priority date	—
Expiry date	Apr 29, 2030

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/55
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

8-hydroxy-5-[(1R)-1-hydroxy-2[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-2(1H)-quinolinone monohydrochloride of formula (I) may be conveniently prepared in a diastereomeric pure form from optically pure precursors that are readily available by simple resolution and asymmetric reduction.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.