Live genetically attenuated malaria vaccine

US8168166B2 · kind B2 · utility

Assignees

• Seattle Biomedical Research Institute · US
• THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH · AU

Inventors

• Stefan H. I. Kappe · Seattle, US
• Kai-Uwe C. Matuschewski · Berlin, DE
• Ann-Kristin Mueller · Dossenheim, DE
• Kelley van Buskirk · Columbia City, US
• Mehdi Labaied · Bainbridge Island, US
• Ahmed Sayed Ibrahim Aly · Seattle, US
• Alan Cowman · Melbourne, AU
• Alexander Gerd Maier · Melbourne, AU

Key dates

• Filing date: May 6, 2008
• Grant date: May 1, 2012
• Expiry date: Dec 17, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Method for inoculating a vertebrate host against malaria, by administering to the host a live Plasmodium organism that is genetically engineered to disrupt a liver-stage-specific gene function.