Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and Rheb
US8168177B2 · kind B2 · utility
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Key dates
| Filing date | Aug 3, 2007 |
| Grant date | May 1, 2012 |
| Priority date | — |
| Expiry date | Feb 19, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/916
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.