Synergistic binder composition, method for making same, and tablets of an active and said binder having advantageous hardness and friability
US8168219B2 · kind B2 · utility
0Cited by
3References
17Claims
0Family size
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Key dates
| Filing date | Nov 30, 2005 |
| Grant date | May 1, 2012 |
| Priority date | — |
| Expiry date | Jul 16, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2077
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Tablets of a pharmaceutical, nutritional or vitamin active compound or composition, e.g. a poorly compressible drug are made by direct compression using a synergistic binder composition of co-processed (a) copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) and (b) microcrystalline cellulose (MCC), in a wt. ratio of (a):(b) of 1-30:99-70, which is spray dried to provide a readily compressible excipient binder powder for such active. The tablets obtained herein have advantageous hardness and friability at an acceptable compression force.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.