Method to modulate hematopoietic stem cell growth
US8168428B2 · kind B2 · utility
21Cited by
2References
3Claims
0Family size
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Key dates
| Filing date | Apr 26, 2007 |
| Grant date | May 1, 2012 |
| Priority date | — |
| Expiry date | Feb 3, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides for compositions and methods for modulating hematopoietic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC modulators found to increase HSC numbers include prostaglandin E2 (PGE2) and agents that stimulate the PGE2 pathway. Conversely, HSC modulators that prevent PGE2 synthesis decrease HSC numbers. HCS modulators may be used in vitro, in vivo, or ex vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.