Subunits of the adenovirus fiber protein and uses thereof as vaccines

US8168750B2 · kind B2 · utility

Assignee

• Abic Biological Laboratories Ltd. · IL

Inventors

• Jacob Pitcovski · Korazim, IL
• Elena Fingerut · Carmiel, IL
• Bezalel Gutter · Jerusalem, IL
• Gilad Gallili · Jerusalem, IL
• Amnon Michael · Hofit, IL

Key dates

• Filing date: Dec 6, 2010
• Grant date: May 1, 2012
• Expiry date: Dec 6, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/10334
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A nucleic acid sequence encoding a fragment of the adenovirus fiber capsid protein, a DNA construct including a replicable expression vector and at least one heterologous nucleic acid, and recombinant protein including fragment of the adenovirus fiber capsid protein. The fragment comprises the C-terminal knob and part of the shaft domain of the fiber protein of these adenoviruses. The use of recombinant proteins as an active ingredient in vaccinating compositions for conferring to an animal immunity against a pathogenic infection by an adenovirus, and methods for vaccinating a domestic bird against a pathogenic adenoviral infection.