Method for preparing propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol
US8168835B2 · kind B2 · utility
2Cited by
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20Claims
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Key dates
| Filing date | May 26, 2010 |
| Grant date | May 1, 2012 |
| Priority date | — |
| Expiry date | Nov 3, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/07
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for preparing a propargylic alcohol catalyzed by 2-morpholinoisobornane-10-thiol (MITH) is disclosed, which includes reacting R1CHO with R2CCH in the presence of R3ZnR4 and MITH, wherein each of R1, R2, R3, and R4, independently, is optionally substituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkylsilyl, heterocycloalkyl, heterocycloalkenyl, aryl, aryloxy, or heteroaryl. The method can give enantioenriched propargylic alcohols with good enantioselective at low loading of MITH.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.