Methods and computer software for detecting splice variants

US8170808B2 · kind B2 · utility

Assignee

• AFFYMETRIX, INC. · US

Inventors

• Alan Williams · Albany, US
• Simon Cawley · Oakland, US
• John Blume · Bellingham, US
• Hui Wang · San Bruno, US
• Tyson A. Clark · Menlo Park, US

Key dates

• Filing date: May 4, 2011
• Grant date: May 1, 2012
• Expiry date: May 4, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G16B25/00
• WIPO field: Computer technology
• WIPO sector: Electrical engineering

Abstract

Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.