High energy electron beam irradiation for the production of immunomodulators in poultry

US8173139B1 · kind B1 · utility

Assignee

• The United States of America, as represented by the Secretary of Agriculture · US

Inventors

• Jackson McReynolds · Bryan, US
• Suresh Pillai · College Station, US
• Palmy Rose Rajan Jesudhasan · College Station, US
• Martha Hernandez · Charenton-le-Pont, FR

Key dates

• Filing date: Sep 10, 2009
• Grant date: May 8, 2012
• Expiry date: Mar 11, 2030

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S424/826
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Populations of Salmonella in animals may be substantially reduced by treatment with a vaccine composition which has been produced by exposing whole, intact cells of a Salmonella species to irradiation with an electron beam under conditions effective to kill the cells. The electron beam irradiated cells of Salmonella are effective for stimulating protective immune responses in the animals against the Salmonella. Induction of these immune responses significantly reduces or eliminates the colonization of the animal by the Salmonella, and consequently reduces or eliminates the shedding of Salmonella in the feces of the animals.