Stabilized polymeric delivery system comprising a water-insoluble polymer and an organic liquid
US8173148B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 10, 2005 |
| Grant date | May 8, 2012 |
| Priority date | — |
| Expiry date | Mar 30, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/622
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a delivery system for the sustained and controlled delivery of a group of bioactive agents. More particularly, the invention relates to a delivery system and a method for delivery of a bioactive agent containing a nucleophilic functional group by means of a biodegradable, sustained-release implant. The implant may be a preformed implant, microparticles or an in situ formed implant. The implant includes a biodegradable thermoplastic polymer, the bioactive agent having a nucleophilic group substituent and a stabilizing associate as well as other optional components. The combination of the stabilizing associate with the bioactive agent prevents and/or minimizes and/or lessens degradation of the thermoplastic polymer by the bioactive agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.