Caspase-2 inhibitors and their biological applications
US8173600B2 · kind B2 · utility
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7Claims
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Key dates
| Filing date | May 2, 2005 |
| Grant date | May 8, 2012 |
| Priority date | — |
| Expiry date | Jul 21, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/81
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to selective new caspase-2 inhibitors that recognize caspase-2 and prevent and block its activity based on the following backbone: 2-Quinolinylcarbonyl-L-Valinyl-L-Aspartyl (methyl ester)-L-Valinyl-L-Alanyl-L-Aspartyl (methyl ester) 2,6-difluorophenyl ester SEQ ID NO:1) and derivatives thereof, SEQ ID NO:1 corresponding to formulae Ia or Ib. Application of the inhibitors for preventing and treating diseases involving caspase-2.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.