N-substituted thiomorpholine derivatives as the inhibitors of dipeptidyl peptidase IV and the pharmaceutical uses thereof

US8173643B2 · kind B2 · utility

Assignee

• Beijing Molecule Science and Technology Co., Ltd. · CN

Inventors

• Song Li · Beijing, CN
• Wu Zhong · Beijing, CN
• Junhai Xiao · Beijing, CN
• Xinghai Ma · Beijing, CN
• Lili Wang · Beijing, CN
• Hongying Liu · Beijing, CN
• Zhibing Zheng · Beijing, CN

Key dates

• Filing date: Jun 1, 2007
• Grant date: May 8, 2012
• Expiry date: Apr 12, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to N-Substituted thiomorpholine compounds of formula I, the possible isomers, the pharmaceutically acceptable salts, the solvates, the hydrates or the prodrugs thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV); and to a method for preparing the compounds of formula I, pharmaceutical compositions comprising the compounds of formula I and use of the compounds of formula II in medical field, particularly in the preparation of medicaments for treating and preventing diabetes (in particular type II diabetes), hyperglycemia, X syndrome, hyperinsulinemia, obesity, atherosclerosis and all kinds of diseases modulated by immune system.