PI 3-kinase inhibitors and methods of their use

US8173647B2 · kind B2 · utility

Inventors

• Gordana Atallah · Fremont, US
• Sarah Bartulis · Emeryville, US
• Matthew Burger · Belmont, US
• Hanne Merritt · Emeryville, US
• Simon Ng · Walnut Creek, US
• Zhi-Jie Ni · Emeryville, US
• Sabina Pecchi · Oakland, US
• Keith B. Pfister · Emeryville, US
• Aaron Smith · Fremont, US
• Charles Voliva · Emeryville, US
• Allan S. Wagman · Belmont, US
• Yanchen Zhang · Kensington, US

Key dates

• Filing date: Feb 6, 2008
• Grant date: May 8, 2012
• Expiry date: May 4, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Phosphatidylinositol (PI) 3-kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases, including proliferative diseases, inflammatory and obstructive airways diseases, allergic conditions, autoimmune and cardiovascular diseases.