Dipeptidyl peptidase inhibitors

US8173663B2 · kind B2 · utility

Assignee

• Takeda Pharmaceutical Company Limited · JP

Inventors

• Jun Feng · San Diego, US
• Stephen L. Gwaltney · San Diego, US
• Jeffrey Alan Stafford · San Diego, US
• Zhiyuan Zhang · Beijing, CN
• Bruce J. Elder · Wynantskill, US
• Paul K. Isbester · New York, US
• Grant J. Palmer · Clifton Park, US
• Jonathon S. Salsbury · Madison, US
• Luckner Ulysse · Albany, US

Key dates

• Filing date: Oct 30, 2007
• Grant date: May 8, 2012
• Expiry date: Mar 2, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising:wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C═NR9; and each L, X, R1, R2, and R3 are as defined herein.