I-pheny 1-3,4-dihydropyrimidin-2(1H)-one derivatives and their use

US8173665B2 · kind B2 · utility

Assignee

• Bayer Pharma Aktiengesellschaft · DE

Inventors

• Heike Gielen-Haertwig · Monheim, DE
• Volkhart Min-Jian Li · Velbert, DE
• Ulrich Rosentreter · Binnen, DE
• Karl-Heinz Schlemmer · Wuppertal, DE
• Swen Allerheiligen · Wuppertal, DE
• Leila Telan · Wuppertal, DE
• Lars Bärfacker · Oberhausen, DE
• Jörg Keldenieh · Wuppertal, DE
• Mary F. Fitzgerald · Yarnton, GB
• Kevin Nash · Seffner, US
• Barbara Albrecht · Wuppertal, DE
• Dirk Meurer · Wunstorf, DE

Key dates

• Filing date: Jul 27, 2009
• Grant date: May 8, 2012
• Expiry date: Feb 1, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to 4-cyanophenyl, 2-sulfanyl, 1-phenyl pyrimidine derivatives, processes for their preparation, and pharmaceutical compositions of the same. Compounds and compositions of the invention are useful in the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, and heart failure development.