Sulfonyl-phenyl-2H-[1,2,4]oxadiazol-5-one derivatives, processes for their preparation and their use as pharmaceuticals

US8173674B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Stefanie Keil · Frankfurt am Main, DE
• Matthias Urmann · Eschborn, DE
• Karl Schoenafinger · Alzenau, DE
• Wolfgang Wendler · Bad Camberg, DE
• Maike Glien · Frankfurt am Main, DE
• Hans-Ludwig Schaefer · Frankfurt am Main, DE
• Eugen Falk · Frankfurt am Main, DE

Key dates

• Filing date: Jun 9, 2009
• Grant date: May 8, 2012
• Expiry date: Jun 16, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to sulfonyl-phenyl-oxadiazolones and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARgamma agonist activity.What are described are compounds of the formula I,in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.