Kappa opioid receptor ligands

US8173678B2 · kind B2 · utility

Assignee

• Research Triangle Institute · US

Inventors

• Frank Ivy Carroll · Durham, US
• Hernan A. Navarro · Chapel Hill, US
• Lawrence Edward Brieaddy · Raleigh, US
• Scott P. Runyon · Morrisville, US
• James B. Thomas · Efland, US

Key dates

• Filing date: Oct 25, 2010
• Grant date: May 8, 2012
• Expiry date: Oct 25, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions.