Patent · US Active

6-O-substituted benzoxazole and benzothiazole compounds and methods of inhibiting CSF-1R signaling

US8173689B2 · kind B2 · utility

3Cited by
59References
6Claims
0Family size

Assignee

Inventors

Key dates

Filing dateMay 8, 2009
Grant dateMay 8, 2012
Priority date—
Expiry dateSep 19, 2029

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D417/12
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Benzoxazole and benzothiazole compounds and the stereoisomers, tautomers, solvates, oxides, esters, and prodrugs thereof and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF-1R.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.