Polypeptides and use thereof

US8173774B2 · kind B2 · utility

Assignee

• ALLIGATOR BIOSCIENCE AB · SE

Inventors

• Christina Furebring · Lund, SE
• Johannes Antonius Gerardus Van Strijp · Schoonhoven, NL
• Petrus J. A. Haas · Utrecht, NL
• Anna Rosén · Austin, US
• Karin Haraldsson · Lund, SE
• Erika Gustafsson · Bjärred, SE
• Lena Schultz · Bethesda, US
• Cornelis Petrus Maria Van Kessel · Bunnik, NL

Key dates

• Filing date: Apr 20, 2007
• Grant date: May 8, 2012
• Expiry date: Apr 24, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of Staphylococcus aureus (‘CHIPS’), the polypeptide comprising a variant of the amino acid sequence of SEQ ID NO:1. Preferably, the polypeptide is a CHIPS variant wherein one or more of the following amino acids is modified: N31, S32, G33, L34, P35, K40, D42, R46, Y48, K50, G52, T53, K54, N55, S56, A57, Q58, K61, E67, K69, L76, N77, P79, D83, L90, K92, K100, K101, S104, K105, S107, Y108, N111 and G112. In a preferred embodiment, the polypeptide is less immunogenic hi humans than the wildtype CHIPS protein. The invention further provides methods of making and using such variant CHIPS polypeptides.