Portable and cartridge-based surface plasmon resonance sensing systems
US8174700B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 28, 2011 |
| Grant date | May 8, 2012 |
| Priority date | — |
| Expiry date | Jan 28, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.