Diagnostic methods relating to Graves' disease and other autoimmune disorders
US8178304B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Feb 20, 2007 |
| Grant date | May 15, 2012 |
| Priority date | — |
| Expiry date | Feb 20, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/564
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides methods of diagnosing Graves' disease (GD), Rheumatoid Arthritis (RA) and other autoimmune diseases in an individual by detecting a disproportionately large fraction of peripheral blood T cells express IGF-1R (CD3+ IGF-R+) compared to normal control samples. In a further embodiment, the invention provides methods of diagnosing, prognosing, staging, and/or monitoring GD, RA and other autoimmune diseases. Or a predisposition thereto in an individual by detecting a disproportionately large fraction of CD3+ IGF-1R+ T cells that express CD45RO+ compared to normal control samples. In a further embodiment, the invention provides a method of diagnosing, prognosing, staging, and/or monitoring GD, RA and other autoimmune diseases or a predisposition thereto in an individual by detecting an increased CD45RO+/RA+ ratio in peripheral blood T cells compared to normal control samples. In addition to peripheral blood T cells, the methods of the invention also can be practiced with test samples comprising T cells harvested from affected orbital tissues. Embodiments directed to the prognosis, staging, and/or monitoring of GD, RA and other autoimmune diseases or a predispositio…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.