Patent · US Active

Pyrimidines reacting with O6-alkylguanine-DNA alkyltransferase fusion protein and method for detecting protein

US8178314B2 · kind B2 · utility

4Cited by

3References

14Claims

0Family size

Assignee

Covalys Biosciences AG · CH

Inventors

Maik Kindermann · Frankfurt, DE
Markus Schwab · Bad Kötzting, DE

Key dates

Filing date	Apr 25, 2006
Grant date	May 15, 2012
Priority date	—
Expiry date	Jan 5, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D495/04
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The invention relates to pyrimidines suitable as substrates for O6-alkylguanine-DNA alkyltransferases (AGT) of formula (I)wherein R1 is hydrogen, lower alkyl, halogen, cyano, trifluoromethyl or azido; R2 is a linker; and L is a label or a plurality of same or different labels. The invention further relates to methods of transferring a label from pyrimidines of formula (I) to O6-alkylguanine-DNA alkyltransferases (AGT) and AGT fusion proteins.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.