Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds

US8178333B2 · kind B2 · utility

Assignee

• Codexis, Inc. · US

Inventors

• Benjamin Mijts · Redwood City, US
• Sheela Muley · Fremont, US
• Jack Liang · San Mateo, US
• Lisa Marie Newman · San Jose, US
• Xiyun Zhang · Fremont, US
• James Lalonde · Palo Alto, US
• Michael D. Clay · Menlo Park, US
• Jun Zhu · Chandler, US
• John M. Gruber · Cameron Park, US
• Jeffrey Colbeck · Davis, US
• John D. Munger, Jr. · Milpitas, US
• Jagadeesh Mavinahalli · Jamkhed, IN
• Roger Sheldon · Rijswijk, NL

Key dates

• Filing date: Jun 23, 2009
• Grant date: May 15, 2012
• Expiry date: Dec 29, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y104/03004
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas,wherein A, M, M′, and R5 are as described herein.