Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof

US8178490B2 · kind B2 · utility

Assignee

• REMPEX PHARMACEUTICALS, INC. · US

Inventors

• Tomasz Glinka · Sunnyvale, US
• Olga Rodny · Mill Valley, US
• Keith A. Bostian · Menlo Park, US
• David Mark Wallace · San Diego, US
• Robert I. Higuchi · Solana Beach, US
• Chun Chow · San Diego, US
• Chi Ching Mak · San Diego, US
• Gavin Hirst · Princeton, US
• Brian Walter Eastman · San Diego, US

Key dates

• Filing date: Nov 5, 2009
• Grant date: May 15, 2012
• Expiry date: Nov 5, 2029

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.