Compounds and compositions as ITPKb inhibitors

US8178526B2 · kind B2 · utility

Assignee

• IRM Inc. · BM

Inventors

• Badry Bursulaya · San Diego, US
• Dai Cheng · San Diego, US
• Jiqing Jiang · San Diego, US
• Donald S. Karanewsky · Princeton Junction, US
• Yi Liu · San Diego, US
• Shifeng Pan · Gilroy, US
• Yongqin Wan · Irvine, US
• Xia Wang · San Diego, US
• Yun Feng Xie · Carlsbad, US
• Yang Yang · Parsippany, US

Key dates

• Filing date: Jun 12, 2008
• Grant date: May 15, 2012
• Expiry date: Feb 20, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).