Azabicyclo [3. 1. O] hexyl derivatives as modulators of dopamine D3 receptors
US8178549B2 · kind B2 · utility
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Key dates
| Filing date | Oct 1, 2008 |
| Grant date | May 15, 2012 |
| Priority date | — |
| Expiry date | Feb 14, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/052
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to novel compounds of formula (I) or a salt thereof:whereinR1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy and SF5; and n is 1 or 2; their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.