Fluorescent probe for peroxynitrite
US8178669B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 14, 2006 |
| Grant date | May 15, 2012 |
| Priority date | — |
| Expiry date | Mar 21, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N31/228
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A compound represented by the following general formula (I):{R1, R3, R6 and R8 are methyl groups and the like, R2 and R7 are cyano groups and the like, R4 and R5 are fluorine atoms and the like, and X is a group represented by the formula (A) [R11 is a monocarboxy-substituted C1-8 alkoxy group and the like, R12, R14 and R15 are hydrogen atoms and the like, and R13 is hydroxy group and the like], provided that the combination of the aforementioned substituents is such a combination that the compound represented by the formula (I) can be substantially non-fluorescent before reacting with peroxynitrite, and the compound represented by the formula (I) in which the group represented by the formula (A) is nitrated after reacting with peroxynitrite can be substantially highly fluorescent}, or a salt thereof, which is useful as a fluorescent probe for peroxynitrite measurement.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.