Method for identifying a compound that modulates SIR2 protein activity
US8180580B2 · kind B2 · utility
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Key dates
| Filing date | Jan 31, 2008 |
| Grant date | May 15, 2012 |
| Priority date | — |
| Expiry date | Mar 25, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method for identifying compounds that modulate the activity of sirtuin deacetylase protein family members. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified nicotinamide inhibition and base exchange site of Sir2 and testing the compound for its ability to modulate the activity of the Sir2 protein. Compositions and methods for preventing or treating diseases or disorders associated with Sir2 are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.