Engineered enzymatically active bacteriophages and methods of uses thereof
US8182804B1 · kind B1 · utility
Assignees
Inventors
Key dates
| Filing date | Sep 12, 2005 |
| Grant date | May 22, 2012 |
| Priority date | — |
| Expiry date | Feb 19, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2795/10243
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also provides genetically engineered bacteriophages expressing the biofilm degrading enzymes and proteins necessary for the phage to replicate in different naturally occurring biofilm producing bacteria. The phages of the invention allow a method of biofilm degradation by the use of one or only a few administration of the phage because the system using these phages is self perpetuating, and capable of degrading biofilm even when the concentration of bacteria within the biofilm is low.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.